Gene information
Official symbol TNFRSF1A
Official full name TNF receptor superfamily member 1A
Gene type protein-coding gene
Chromosome12p13.31
Alias symbolTNF-R; TNFAR; TNFR60; TNF-R-I; CD120a; TNF-R55
Previous symbolTNFR1
Gene familyCD molecules; Tumor necrosis factor receptor superfamily
Resources
Entrez Gene 7132
HGNC HGNC:11916
Ensembl ENSG00000067182
Vega OTTHUMG00000168267
UCSC uc001qnu.4
GO terms: 75 records
GO Description Category LogP Number of genes Detail
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001959 regulation of cytokine-mediated signaling pathway GO Biological Processes -13.0991884 33 More
GO:0003170 heart valve development GO Biological Processes -11.9253160 20 More
GO:0003176 aortic valve development GO Biological Processes -8.77845673 13 More
GO:0003177 pulmonary valve development GO Biological Processes -7.13135320 9 More
GO:0003330 regulation of extracellular matrix constituent secretion GO Biological Processes -6.00516542 6 More
GO:0005031 tumor necrosis factor receptor activity GO Molecular Functions -3.60391289 3 More
GO:0005035 death receptor activity GO Molecular Functions -4.72638472 4 More
GO:0006631 fatty acid metabolic process GO Biological Processes -20.3287405 33 More
GO:0006690 icosanoid metabolic process GO Biological Processes -21.0788451 23 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006974 cellular response to DNA damage stimulus GO Biological Processes -1.56334957 15 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO Biological Processes -1.93848138 3 More
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO Biological Processes -5.52642112 8 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0010611 regulation of cardiac muscle hypertrophy GO Biological Processes -13.5611908 22 More
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO Biological Processes -3.24021630 5 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0014741 negative regulation of muscle hypertrophy GO Biological Processes -8.77845673 13 More
GO:0014743 regulation of muscle hypertrophy GO Biological Processes -14.1608908 23 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0030856 regulation of epithelial cell differentiation GO Biological Processes -15.4645914 35 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0033209 tumor necrosis factor-mediated signaling pathway GO Biological Processes -6.18341292 8 More
GO:0033559 unsaturated fatty acid metabolic process GO Biological Processes -16.8056258 19 More
GO:0034612 response to tumor necrosis factor GO Biological Processes -24.4651326 32 More
GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.4049069 20 More
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.8380655 19 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043120 tumor necrosis factor binding GO Molecular Functions -4.66190148 3 More
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.71585030 18 More
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.04470175 15 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043502 regulation of muscle adaptation GO Biological Processes -16.8828965 29 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045601 regulation of endothelial cell differentiation GO Biological Processes -11.5275821 17 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060759 regulation of response to cytokine stimulus GO Biological Processes -13.7003447 35 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071356 cellular response to tumor necrosis factor GO Biological Processes -22.5666334 29 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0097190 apoptotic signaling pathway GO Biological Processes -11.7839485 23 More
GO:0097191 extrinsic apoptotic signaling pathway GO Biological Processes -9.74858067 13 More
GO:0097193 intrinsic apoptotic signaling pathway GO Biological Processes -4.54525889 10 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
GO:1901550 regulation of endothelial cell development GO Biological Processes -5.90191637 5 More
GO:1903053 regulation of extracellular matrix organization GO Biological Processes -8.17680088 15 More
GO:1903054 negative regulation of extracellular matrix organization GO Biological Processes -8.11586193 6 More
GO:1903140 regulation of establishment of endothelial barrier GO Biological Processes -5.90191637 5 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:1905314 semi-lunar valve development GO Biological Processes -10.3278393 15 More
KEGG pathways: 28 records
KEGG Description Category LogP Number of genes Detail
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04064 NF-kappa B signaling pathway KEGG Pathway -10.0294934 14 More
hsa04071 Sphingolipid signaling pathway KEGG Pathway -4.55426967 9 More
hsa04210 Apoptosis KEGG Pathway -6.60042966 12 More
hsa04217 Necroptosis KEGG Pathway -8.49909048 15 More
hsa04380 Osteoclast differentiation KEGG Pathway -7.05199617 21 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa04920 Adipocytokine signaling pathway KEGG Pathway -10.4150431 19 More
hsa04931 Insulin resistance KEGG Pathway -8.40376708 21 More
hsa04932 Non-alcoholic fatty liver disease KEGG Pathway -11.2628136 17 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa05014 Amyotrophic lateral sclerosis KEGG Pathway -1.64954984 10 More
hsa05022 Pathways of neurodegeneration - multiple diseases KEGG Pathway -4.18311884 18 More
hsa05130 Pathogenic Escherichia coli infection KEGG Pathway -9.84822677 18 More
hsa05131 Shigellosis KEGG Pathway -5.26807538 14 More
hsa05132 Salmonella infection KEGG Pathway -7.42305681 17 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05166 Human T-cell leukemia virus 1 infection KEGG Pathway -5.08552863 13 More
hsa05167 Kaposi sarcoma-associated herpesvirus infection KEGG Pathway -9.05308086 17 More
hsa05168 Herpes simplex virus 1 infection KEGG Pathway -3.99478875 17 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
hsa05418 Fluid shear stress and atherosclerosis KEGG Pathway -23.1665561 27 More
Drug-Gene interaction
view
Related drugs: 4 records
Related studies: 4 records
Molecular factor Omics type Application Objective MI type Reference
NM_001065.4:c.362G>A genomics myocardial infarction[diagnosis] myocardial infarction Poirier O et al. Eur J Hum Genet. 2004
tumor necrosis factor receptor superfamily member 1A proteomics death[prognosis (bad)] acute myocardial infarction Ueland T et al. J Am Coll Cardiol. 2005
tumor necrosis factor receptor superfamily member 1A proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Mielczarek-Palacz A et al. Wiad Lek. 2011
tumor necrosis factor receptor superfamily member 1A proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Carlsson AC et al. Atherosclerosis. 2018
All rights reserved: Soochow University Center for Systems Biology